Clayton Pierce, a top agent, is questioning his loyalty after 20 years of service, having sacrificed his personal life and relationships. During a debriefing, he's unknowingly given the drug Oblivion, causing permanent memory loss and erasing his identity. As the effects become irreversible, Clayton must turn to his ex-wife Kate for help to find the antidote before it's too late.
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As an undercover anti-terrorist agent, he's handed a drug that erases his memories, giving him a 48-hour window to regain his identity and escape a deadly fate.