A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.
Alice wakes up in the Raccoon City hospital after the area has been overrun by zombies, and must now make it out of the city before a nuclear bomb is dropped.
Survivors of the Raccoon City catastrophe travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against the evil Umbrella Corp.
While still out to destroy the evil Umbrella Corporation, Alice joins a group of survivors living in a prison surrounded by the infected who also want to relocate to the mysterious but supposedly unharmed safe haven known only as Arcadia.
Alice fights alongside a resistance movement to regain her freedom from an Umbrella Corporation testing facility.
Alice returns to the Hive in Raccoon City, a place where her nightmare began, as the Umbrella Corporation prepares for a final showdown with the last remaining survivors of the apocalypse.