In the year 2046, Earth has been transformed by alien visitors, who arrived over 30 years prior. The town of Defiance, formerly St. Louis, is home to a diverse population, including the mysterious Nolan and his charge Irisa. As they settle in, they must navigate the complex relationships between the town's leaders, including Mayor Amanda Rosewater, and its residents, including the powerful Rafe McCawley and the ambitious alien Tarrs.
In a future Earth largely devastated after lengthy war with alien invaders, J...