When Henry DeTamble meets Clare Abshire in a Chicago library they both understand that he is a time traveler, but she knows much more about him as he has not yet been to the times and places where they have already met. He falls in love with her, as she has already with him, but his continuing unavoidable absences while time traveling - and then returning with increasing knowledge of their future - makes things ever more difficult for Clare.
The Time Traveler's Wife
A Chicago librarian has a gene that causes him to involuntarily time travel, creating complications in his marriage.