Daigo Kagemitsu, a samurai general during Japan’s Warring States period, makes an offer to 48 demons in exchange for complete control over the country by offering his unborn baby’s body parts. When the baby is born, Daigo throws him into a river expecting him to die. However, a kind sage rescues and adopts the boy, who later becomes known as Hyakkimaru. Hyakkimaru uses his prosthetic limbs acquired from eliminating demons to fight against them and retrieve their body parts, while also seeking out thieves like Dororo who have been helping him on his quest.
A young thief named Dororo becomes fascinated with Hyakkimaru's monster-hunti...