A riot breaks out in Los Angeles on June 21, 2028, after water privatization, allowing a group of brothers and miscreants to rob a bank. They steal from wealthy hostages and escape, but during a police chase, one of them is killed and two are critically wounded. They seek medical attention at the Hotel Artemis, a hospital for criminals, where they meet other guests and a mysterious figure named Crosby Franklin, who is on his way to the hotel with his critically ill father.