In 16th century Florence, Michelangelo Buonarroti, a genius artist, is struggling to complete the Sistine Chapel's ceiling and is reduced to poverty. After Pope Julius II's death, Michelangelo becomes obsessed with finding the finest marble to complete his tomb. When Leo X, a rival family's leader, becomes pope, he commissions Michelangelo to work on the San Lorenzo basilica's façade.
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The biographical drama follows the life and artistic journey of Michelangelo Buonarroti, a renowned Italian artist, sculptor, painter, architect, and poet.